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8. What do lipid-soluble drugs, steroids, and thyroid hormones bind...

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8. What do lipid-soluble drugs, steroids, and thyroid hormones bind...

8.

What do lipid-soluble drugs, steroids, and thyroid hormones bind to?

a.

Cytokine receptors

b.

Tyrosine kinase receptors

c.

Intracellular receptors

d.

G protein-coupled receptors

e.

Transmembrane ion channels



What receptors involve JAK and STAT molecules and are activated by growth hormone,

erythropoietin and interferon?

a.

Cytokine receptors

b.

Tyrosine kinase receptors

c.

Intracellular receptors

d.

G protein-coupled receptors

e.

Transmembrane ion channels



11.

If KD is large:


 

a.Affinity is high.

b.Affinity is low.

c.Potency is high.

d.Potency is low.



An elderly man enters the hospital with myocardial infarction and a severe

ventricular arrhythmia. The antiarrhythmic drug chosen has a narrow therapeutic

window. The minimum toxic plasma concentration is 1.5 times the minimum

therapeutic plasma concentration. The half-life is 6 hours. It is essential to maintain

the plasma concentration above the minimum therapeutic level to prevent a possible

lethal arrhythmia. Of the following, the most appropriate dosing regimen would be:

a.

Once a day

b.

Twice a day

c.

Four times a day

d.

Constant intravenous infusion



 

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