Imagine that you are sitting in your A&P class one day when the person next to you sneezes without covering their mouth. The water droplets from the sneeze contain a rhinovirus, a virus responsible for the common cold. You inhale the rhinovirus and it manages to escape your respiratory defense systems and invades the mucosa membrane of your nose. Once inside the epithelial cells of the mucosa membrane, the rhinovirus takes over the cell's machinery to cause it to produce more rhinovirus particles. As the virus particle multiplies and spreads, you have cells in the upper respiratory tract that are infected with the viral particles and you also have free viral particles in the interstitial tissues in the upper respiratory tract. Let's follow the coordinated immune response to this "common cold".
What aspects of the immune response are responsible for the symptoms you suffer during the common cold (sore throat, runny nose, nasal congestion, sneezing and coughing, and sometimes a mild fever)?
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