Many critics have compared Of Mice and Men to influences from John Milton's Paradise Lost and the Bible. And, indeed, many of the events of Steinbeck's novel parallel the biblical stories of the loss of paradise and Cain and Abel. Of particular relevance to Of Mice and Men is the question posed in the biblical story of Cain and Abel: Am I my brother's keeper? Also relevant is the story of Adam and Eve and their being cast out of Eden. Although a biblical story, this story is also the basis of John Milton's epic poem, Paradise Lost, which describes Lucifer's (Satan's) fall from heaven and the creation of hell, as well as Eve and Adam's fall from grace.
Steinbeck was influenced by the Arthurian legends as well, and the fellowship embodied in these tales also is relevant to Of Mice and Men. The loyalty and companionship, the love and trust shown between George and Lennie, are similar to the comradeship of the knights of the Arthurian tales. The knight's pledge to help those who are less fortunate and to defend the poor and powerless is also a motif apparent in Of Mice and Men. Additionally, the idea that nothing endures forever — especially perfection — reflects an Arthurian influence.
Throughout his novel Steinbeck uses nature to reflect the mood of the scenes and provide locations that reinforce themes. Steinbeck was a lover of nature, particularly the California countryside, and he uses nature in this story as both a place of sanctuary and also a reflection of foreboding.
