The most powerful moments of the scene are the final ones in which Macbeth calls for the cancellation of the bond between himself and the world. "Bond" is more than simply a simile from the world of legal jargon. Just as Lady Macbeth earlier wanted to lose her sex, Macbeth now desires to be rid of his humanity. His direct connection with the natural world into which he was born threatens to keep him "pale" or fearful. A final point to make about these lines is the way in which the rhythmical stress falls unusually on the first syllable of the word "cancel":
"And, with thy bloody and invisible hand
Cancel and tear to pieces that great bond . . . ." (49–50)
Metrically, as well as dramatically, Macbeth is moving inexorably toward his tragic destiny. Meanwhile his wife, once so calm and collected, is losing that composure. Macbeth's line "Thou marvell'st at my words" suggests, like a stage direction, some moving response in her.
